Keeping the right dosage
نویسندگان
چکیده
منابع مشابه
Generating a Wnt switch: it’s all about the right dosage
Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit different intracellular responses. These findings not only provide new insights into the molecular mecha...
متن کاملKeeping off the wrong track on the right side: planning for transcatheter caval valve implantation.
P resence of severe tricuspid regurgitation (TR) is associated with increasing mortality and morbidity in patients with heart failure (1). Severe TR leads to reversal of blood flow into the inferior vena cava (IVC), resulting in wasted myocardial work and worsening of right heart function, congestive hepatopathy, and ascites. In a previous Editor’s Page, we highlighted the peculiarities of bloo...
متن کاملCardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right.
Phosphorylation of the cardiac ryanodine receptor (RyR2) is a key mechanism regulating sarcoplasmic reticulum (SR) Ca2+ release. Differences in opinion have arisen over the importance assigned to specific phosphorylation sites on RyR2, over the kinase (s) suggested to directly phosphorylate RyR2 and surrounding the possibility that altered phosphorylation of RyR2 is associated with contractile ...
متن کاملSaving our newborns by doing the basics right--and keeping it simple.
In view of the absence of significant reduction in SA's neonatal mortality rate over the past decade and the country failing dismally to reach this year's Millennium Development Goal (MDG) of reducing its 1990 child mortality rate by two-thirds, Izindaba quizzed Zar on the most vital interventions required. Antenatal steroids to mature a baby' s lungs when its mother is in preterm labour, the n...
متن کاملthe effect of keeping reflective journals by language instructors on the process of reading comprehension among iranian high school students
خواندن ودرک مطلب از مهمترین مهارتها در یادگیری زبان خارجی محسوب می شود. این تحقیق تاثیر برگه های تامل برانگیز هدایت شده را در ارتقاع مهارت خواندن ودر ک مطلب در دانش اموزان دبیرستانی ایرانی بررسی می نماید. ازمجموع ?2 دانش آموز سال چهارم دبیرستان شهید رجایی شهرستان اسلامشهر¸ پس از اجرای آزمون استاندارد ((nelson 150a تعداد 39 دانش آموز که نمرات آنها یک سطح انحراف معیار بالاتر یا پایین تر ازمعدل قر...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2007
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb0207-97